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Conjugated estrogens
Estrone sulfate, the primary active component in conjugated estrogens (constitutes about 50 to 70% of total content).
Equilin sulfate, the second most major active component in conjugated estrogens (constitutes about 20 to 30% of total content).
Combination of
Estrone sulfateEstrogen
Equilin sulfateEstrogen
17α-Dihydro-equilin sulfateEstrogen
Clinical data
Trade namesCenestin, Enjuvia, Congest, C.E.S., Premarin, Prempro (with MPA), Premphase (with MPA), others
AHFS/Drugs.comConsumer Drug Information
Pregnancy categoryX
Routes of administrationBy mouth, topical, vaginal, intravenous injection, intramuscular injection [1] [2]
Drug classEstrogen
ATC codeG03CA57 ( WHO )
Legal status
Legal statusIn general: ℞ (Prescription only)
Pharmacokinetic data
BioavailabilityVariable [3]
Protein bindingHigh (to albumin and SHBG) [3] [1]
MetabolismLiver [3] [1]
Elimination half-lifeEstrone: 26.7 hours Estrone (BA): 14.8 hours Equilin: 11.4 hours [4]
ExcretionUrine [3]

J Urol. 81-586. Moore E, Jamestown S, Boyko E, Scholes D, Fihn S. Duplex premarin vaginal coupon and required addition hole: Temporal premarin vaginal coupons in postmenopausal women. Obstet Gynecol. 17-323. Boyko E, Fihn S, Scholes D, Chen C, Normand E, Yarbro P. Diabetesand the growth of reported urinary tract infection in decreasing women.

New Chad, NY: Pfizer Inc; 2015. Bachmann G, Bouchard C, Hoppe D, et al. premarin vaginal creme

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Premarin alternative names drug:
  1. Cenestin 0.625 mg
  2. Climopax 0.625 mg
  3. Elredin 0.625 mg
  4. Enjuvia 0.625 mg
  5. Neradin 0.625 mg
  6. Premphase 0.625 mg
  7. Prempro 0.625 mg
  8. Presomen 0.625 mg

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