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Mirtazapine
Clinical data
Trade namesRemeron, others
AHFS/Drugs.comMonograph
MedlinePlusa697009
License dataUS   FDA: Mirtazapine
Pregnancy categoryAU: B3 US: C (Risk not ruled out)
Routes of administrationBy mouth (tablets)
ATC codeN06AX11 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability50% [3] [4] [5] [6]
Protein binding85% [3] [4] [5] [6]
MetabolismLiver (CYP1A2, CYP2D6, CYP3A4) [3] [4] [5] [6] [7]
MetabolitesDesmethylmirtazapine (contributes 3–10% of activity) [7]
Elimination half-life20–40 hours [3] [4] [5] [6]
ExcretionUrine: 75% [3] Feces: 15% [3] [4] [5] [6]

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Albeck JH. Withdrawal and detoxification from benzodiazepine dependence: a potential role for clonazepam.Minimally clinically significant.

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Drugs. om provides accurate and independent information on more than 24, 00 prescription drugs, over-the-counter medicines and natural products.Am J Psychiatry.

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Psychol Med Minimal clinically important difference on the Beck Depression Inventory--II according to the patient s perspective.Typically people in our interviews who had been prescribed mirtazapine had not responded to other antidepressants such as SSRIs or tricyclics.

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