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Isosorbide mononitrate extended-release tablets are contraindicated in patients who have shown hypersensitivity or idiosyncratic reactions to other nitrates or nitrites. Amplification of the vasodilatory effects of isosorbide mononitrate by sildenafil can result in severe hypotension.28-w.
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Studies of nitroglycerin an organic nitrate with a very short half-life have shown that daily dose-free intervals of 10 to 12 hours are usually sufficient to minimize tolerance.2017 Sep; 9 632-639.
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It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload.
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