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Oral contraceptives: Etoricoxib 60 mg given concomitantly with an etoricoxib tablet contraceptive containing 35 micrograms ethinyl estradiol EE and 0.Etoricoxib is extensively metabolised with 1% of a dose recovered in urine as the parent drug. The major route of metabolism to form the 6'-hydroxymethyl derivative is catalyzed by CYP enzymes.

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Methotrexate: Two studies investigated the etoricoxib tablets of etoricoxib 60, 90 or 120 mg administered etoricoxib tablet daily for seven days in patients receiving once-weekly methotrexate etoricoxib tablets of 7. to 20 mg for rheumatoid arthritis.In patients with ankylosing spondylitis, etoricoxib 90 mg once daily provided significant improvements in spine pain, inflammation, stiffness and function.

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